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J Cell Physiol. 2018 Feb;233(2):830-848. doi: 10.1002/jcp.25778. Epub 2017 Mar 31.

Therapeutic effects of curcumin in inflammatory and immune-mediated diseases: A nature-made jack-of-all-trades?

Author information

1
Department of Medical Immunology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
3
Student Research Committee, Nanotechnology Research Center, Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4
Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, Missouri.
5
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
6
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Curcumin is a dietary polyphenol from turmeric with numerous pharmacological activities. Novel animal and human studies indicate that curcumin can affect different immune cells, such as various T lymphocyte subsets, macrophages, dendritic cells, B lymphocytes and natural killer cells, which results in decreasing severity of various diseases with immunological etiology. The present review provides a comprehensive overview of the effects of curcumin on different immune cells and immune system-related diseases.

KEYWORDS:

autoimmune disease; curcumin; immune system; inflammation

PMID:
28059453
DOI:
10.1002/jcp.25778
[Indexed for MEDLINE]

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