Format

Send to

Choose Destination
Mult Scler. 2017 Nov;23(13):1748-1756. doi: 10.1177/1352458516685416. Epub 2017 Jan 6.

Clinical characteristics of late-onset neuromyelitis optica spectrum disorder: A multicenter retrospective study in Korea.

Author information

1
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea/Neuroscience Center, Samsung Medical Center, Seoul, Korea.
2
Department of Neurology, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Bucheon, Korea.
3
Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.
4
Department of Neurology, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Changwon, Korea.
5
Department of Neurology, Yeungnam University College of Medicine, Daegu, Korea.
6
Department of Neurology, Ajou University College of Medicine, Suwon, Korea.
7
Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
8
Department of Neurology, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, Korea.
9
Department of Neurology, Korea University College of Medicine, Seoul, Korea.
10
Department of Neurology, College of Medicine, Dong-A University, Busan, Korea.
11
Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
12
Department of Neurology, College of Medicine, Kosin University, Busan, Korea.
13
Department of Neurology, School of Medicine, Eulji University, Seoul, Korea.

Abstract

BACKGROUND:

There are currently few studies regarding late-onset neuromyelitis optica spectrum disorder (LO-NMOSD).

OBJECTIVE:

We aimed to describe the characteristic features of patients with LO-NMOSD in Korea.

METHODS:

Anti-aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum disorder (NMOSD) from nine tertiary hospitals were reviewed retrospectively. The patients were divided into two groups based on age of onset: LO-NMOSD (⩾50 years of age at onset) versus early-onset neuromyelitis optica spectrum disorder (EO-NMOSD) (<50 years of age at onset). Clinical, laboratory, and magnetic resonance imaging (MRI) parameters were investigated.

RESULTS:

Among a total of 147 patients (125 female; age of onset, 39.4 ± 15.2 years), 45 patients (30.6%) had an age of onset of more than 50 years. Compared to patients with EO-NMOSD, patients with LO-NMOSD had more frequent isolated spinal cord involvement at onset (64.4% vs 37.2%, p = 0.002), less frequent involvement of the optic nerve (40.0% vs 67.7%, p = 0.002), and less frequent brain MRI lesions (31.1% vs 50.0%, p = 0.034). Furthermore, there was a significant positive correlation between age of onset and Expanded Disability Status Scale (EDSS) score at last follow-up ( r = 0.246, p = 0.003).

CONCLUSION:

Age of onset could be an important predictor of lesion location and clinical course of patients with NMOSD.

KEYWORDS:

Neuromyelitis optica (NMO); age of onset; late-onset neuromyelitis optica; neuromyelitis optica spectrum disorder (NMOSD); seropositive neuromyelitis optica spectrum disorder

PMID:
28058965
DOI:
10.1177/1352458516685416
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center