Send to

Choose Destination
Iran Red Crescent Med J. 2016 Jun 19;18(8):e29166. doi: 10.5812/ircmj.29166. eCollection 2016 Aug.

Protective Effects of Co-Enzyme Q10 on Thioacetamide-Induced Acute Liver Damage and Its Correlation With Behavioral, Biochemical, and Pathological Factors.

Author information

Student Research Committee, Shiraz University of Medical Sciences, Shiraz, IR Iran.
Organ Transplant Research Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, IR Iran.
International Branch, Shiraz University of Medical Sciences, Kish, IR Iran.
Department Of Pharmacology, Fasa University of Medical Sciences, Shiraz, IR Iran.
Center of Comparative and Experimental Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran.
Histomorphometry and Stereology Research Centre, Shiraz University of Medical Sciences, Shiraz, IR Iran.



Acute liver damage may be followed by biochemical, behavioral, and pathological alterations, which can result in serious complications and even death.


In this experimental study we determined whether coenzyme Q10 (CoQ10), a common supplementary medicine known to have protective, antioxidative, and anti-inflammatory effects in cells, has any protective effect against thioacetamide (TAA)-induced liver damage and its related neurobehavioral alterations in rats.


In this experimental study forty-eight Wistar rats were divided randomly into four groups (n = 12): C1 was the control group; C2 received a single-dose of TAA (350mg/kg; intraperitoneally) without any other treatment; E1 received TAA + 5 mg/kg CoQ10 (intraperitoneally); and E2 received TAA + 10 mg/kg CoQ10. After sacrificing the rats, liver enzymes and plasma-ammonia (NH4) were measured and histopathological analyses of the livers were carried out. Elevated-plus-maze, open-field, and forced-swimming tests were also performed to investigate behavioral correlations.


The serum levels of alanine-aminotransferase (ALT), aspartate-aminotransferase (AST), and NH4 show significant increases (P < 0.05). The groups treated with CoQ10 were shown to have significantly lower clinical grade of encephalopathy (P = 0.001), higher locomotor activity (P = 0.000), and lower levels of depression (P = 0.000). Furthermore, it was also shown that CoQ10 treatment may lead to significant decreases in scores of centrilobular necrosis, apoptosis, inflammatory cell infiltration, vacuolization, and liver necrosis (P < 0.05).


Overall, CoQ10 was determined to have positive effects on liver injury and its related behavioral and biochemical changes.


Acute liver Failure; Behavioral Symptoms; Coenzyme Q10; Hyperammonemia; Thioacetamide

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center