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Neuropsychologia. 2017 Oct;105:70-83. doi: 10.1016/j.neuropsychologia.2017.01.001. Epub 2017 Jan 3.

The inferior parietal lobule and temporoparietal junction: A network perspective.

Author information

1
Princeton Neuroscience Institute and Department of Psychology, Princeton University, Washington Road, Princeton, NJ 08544, USA. Electronic address: kajsa@igelstrom.com.
2
Princeton Neuroscience Institute and Department of Psychology, Princeton University, Washington Road, Princeton, NJ 08544, USA. Electronic address: graziano@princeton.edu.

Abstract

Information processing in specialized, spatially distributed brain networks underlies the diversity and complexity of our cognitive and behavioral repertoire. Networks converge at a small number of hubs - highly connected regions that are central for multimodal integration and higher-order cognition. We review one major network hub of the human brain: the inferior parietal lobule and the overlapping temporoparietal junction (IPL/TPJ). The IPL is greatly expanded in humans compared to other primates and matures late in human development, consistent with its importance in higher-order functions. Evidence from neuroimaging studies suggests that the IPL/TPJ participates in a broad range of behaviors and functions, from bottom-up perception to cognitive capacities that are uniquely human. The organization of the IPL/TPJ is challenging to study due to the complex anatomy and high inter-individual variability of this cortical region. In this review we aimed to synthesize findings from anatomical and functional studies of the IPL/TPJ that used neuroimaging at rest and during a wide range of tasks. The first half of the review describes subdivisions of the IPL/TPJ identified using cytoarchitectonics, resting-state functional connectivity analysis and structural connectivity methods. The second half of the article reviews IPL/TPJ activations and network participation in bottom-up attention, lower-order self-perception, undirected thinking, episodic memory and social cognition. The central theme of this review is to discuss how network nodes within the IPL/TPJ are organized and how they participate in human perception and cognition.

KEYWORDS:

Angular gyrus; Frontoparietal executive control network; Internal cognition; Posterior superior temporal sulcus; Supramarginal gyrus; Ventral parietal cortex

[Indexed for MEDLINE]

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