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Trends Microbiol. 2017 Apr;25(4):316-328. doi: 10.1016/j.tim.2016.12.004. Epub 2017 Jan 3.

Helicobacter pylori: A Paradigm Pathogen for Subverting Host Cell Signal Transmission.

Author information

1
Otto von Guericke University, Institute of Experimental Internal Medicine, Medical Faculty, Leipziger Str. 44, 39120 Magdeburg, Germany. Electronic address: Naumann@med.ovgu.de.
2
Otto von Guericke University, Institute of Experimental Internal Medicine, Medical Faculty, Leipziger Str. 44, 39120 Magdeburg, Germany.
3
Friedrich Alexander University Erlangen-Nuremberg, Department Biology, Division of Microbiology, Staudtstr. 5, 91058 Erlangen, Germany.

Abstract

Helicobacter pylori colonizes the gastric mucosa in the human stomach and represents a major risk factor for peptic ulcer disease and gastric cancer. Here, we summarize our current knowledge of the complex impact of H. pylori on manipulating host signalling networks, that is, by the cag pathogenicity island (cagPAI)-encoded type IV secretion system (T4SS). We show that H. pylori infections reflect a paradigm for interspecies contact-dependent molecular communication, which includes the disruption of cell-cell junctions and cytoskeletal rearrangements, as well as proinflammatory, cell cycle-related, proliferative, antiapoptotic, and DNA damage responses. The contribution of these altered signalling cascades to disease outcome is discussed.

KEYWORDS:

T4SS; gastric cancer; inflammation; pathogen; signalling pathways

PMID:
28057411
DOI:
10.1016/j.tim.2016.12.004
[Indexed for MEDLINE]

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