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Curr Top Dev Biol. 2017;121:253-285. doi: 10.1016/bs.ctdb.2016.07.010. Epub 2016 Aug 12.

Unraveling the Neurobiology of Sleep and Sleep Disorders Using Drosophila.

Author information

1
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.
2
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States. Electronic address: kayser@mail.med.upenn.edu.

Abstract

Sleep disorders in humans are increasingly appreciated to be not only widespread but also detrimental to multiple facets of physical and mental health. Recent work has begun to shed light on the mechanistic basis of sleep disorders like insomnia, restless legs syndrome, narcolepsy, and a host of others, but a more detailed genetic and molecular understanding of how sleep goes awry is lacking. Over the past 15 years, studies in Drosophila have yielded new insights into basic questions regarding sleep function and regulation. More recently, powerful genetic approaches in the fly have been applied toward studying primary human sleep disorders and other disease states associated with dysregulated sleep. In this review, we discuss the contribution of Drosophila to the landscape of sleep biology, examining not only fundamental advances in sleep neurobiology but also how flies have begun to inform pathological sleep states in humans.

KEYWORDS:

Autism; Development; Drosophila; Insomnia; Neurodegeneration; Psychiatry; Sleep; Synapse

PMID:
28057302
DOI:
10.1016/bs.ctdb.2016.07.010
[Indexed for MEDLINE]

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