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BMC Pharmacol Toxicol. 2017 Jan 5;18(1):1. doi: 10.1186/s40360-016-0111-8.

Deflazacort: therapeutic index, relative potency and equivalent doses versus other corticosteroids.

Author information

1
Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy. lparente@unisa.it.

Abstract

BACKGROUND:

Deflazacort is a synthetic corticosteroid characterized by a favourable pharmacokinetic profile, peculiar pharmacodynamic properties and a good safety profile. However, to the best of our knowledge, no dose-conversion table based on direct comparison of relative potencies between deflazacort and other main corticosteroids is currently available in scientific literature.

MAIN BODY:

This paper, while reporting a brief review of deflazacort pharmacological properties, its efficacy and tolerability in different clinical areas, has been designed with the specific aim of providing a new dose-conversion table of corticosteroids, including for the first time also deflazacort.

SHORT CONCLUSION:

We suggest that this new conversion table could be a useful tool for physicians who need to select the appropriate dose of deflazacort in their clinical practice.

KEYWORDS:

Corticosteroids; Deflazacort; Equipotency ratio; Relative potencies; Therapeutic efficacy; Tolerability

PMID:
28057083
PMCID:
PMC5216559
DOI:
10.1186/s40360-016-0111-8
[Indexed for MEDLINE]
Free PMC Article

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