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Nutr Neurosci. 2018 Apr;21(3):219-223. doi: 10.1080/1028415X.2016.1266133. Epub 2017 Jan 5.

A double- blind, randomized, and placebo-controlled clinical trial with omega-3 polyunsaturated fatty acids (OPFA ɷ-3) for the prevention of migraine in chronic migraine patients using amitriptyline.

Author information

1
a Center of Neurology and Headache of Piauí , Teresina , Brazil.
2
b Botica Pharmacies , Teresina , Brazil.
3
c Santo Agostinho College , Teresina , Brazil.
4
d Department of Neurology , Universidade Federal do Piauí , Teresina , Brazil.

Abstract

OBJECTIVE:

To determine the prophylactic effect of OPFAϖ-3 in migraine.

SUBJECTS AND METHODS:

This was a prospective, experimental, controlled, double-blind, and with comparison groups study. Sixty patients diagnosed with chronic migraine, according to the criteria of the International Classification of Headache Disorders, Third Edition (beta version) (ICHD-3β), were prophylactically treated with amitriptyline. They were divided into two equal groups: in group 1, prophylaxis was associated with OPFAϖ-3 and in group 2 with placebo. After 60 days, both groups were assessed by a second researcher.

RESULTS:

Of the 60 patients with chronic migraine, only 51 patients (15 men and 36 women) completed the treatment. The group that received OPFAϖ-3 consisted of 27 (52.9%) patients (six men and 21 women), while the control group was equal to 24 (47.1%) patients (nine men and 15 women). These differences were not significant (χ2 = 1.428; P = 0.375). In 66.7% (18/27) of the patients who used OPFAϖ-3, there was a reduction of more than 80.0% per month in the number of days of headache, while in the control group, the same improvement occurred in 33.3% (8/24) of patients. This difference was significant (χ2 = 5.649; P = 0.036).

CONCLUSIONS:

Polyunsaturated omega 3 fatty acids (OPFAϖ-3) are useful for prophylaxis of migraine attacks.

KEYWORDS:

Fatty acids; Migraine; Omega 3; Prophylaxis

PMID:
28056704
DOI:
10.1080/1028415X.2016.1266133
[Indexed for MEDLINE]

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