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ACS Nano. 2017 Feb 28;11(2):1172-1179. doi: 10.1021/acsnano.6b06861. Epub 2017 Jan 9.

Reconfigurable Three-Dimensional Gold Nanorod Plasmonic Nanostructures Organized on DNA Origami Tripod.

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CAS Key Laboratory of Nanosystems and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Atlanta, Georgia 30322, United States.
Institute of Applied Physics and Computational Mathematics , Beijing 100088, China.
Wyss Institute for Biologically Inspired Engineering, Harvard University , Boston, Massachusetts 02115, United States.
Department of Systems Biology, Harvard Medical School , Boston, Massachusetts 02115, United States.
University of Chinese Academy of Sciences , Beijing 100049, China.


Distinct electromagnetic properties can emerge from the three-dimensional (3D) configuration of a plasmonic nanostructure. Furthermore, the reconfiguration of a dynamic plasmonic nanostructure, driven by physical or chemical stimuli, may generate a tailored plasmonic response. In this work, we constructed a 3D reconfigurable plasmonic nanostructure with controllable, reversible conformational transformation using bottom-up DNA self-assembly. Three gold nanorods (AuNRs) were positioned onto a reconfigurable DNA origami tripod. The internanorod angle and distance were precisely tuned through operating the origami tripod by toehold-mediated strand displacement. The transduction of conformational change manifested into a controlled shift of the plasmonic resonance peak, which was studied by dark-field microscopy, and agrees well with electrodynamic calculations. This new 3D plasmonic nanostructure not only provides a method to study the plasmonic resonance of AuNRs at prescribed 3D conformations but also demonstrates that DNA origami can serve as a general self-assembly platform for constructing various 3D reconfigurable plasmonic nanostructures with customized optical properties.


DNA nanotechnology; DNA origami; dark-field scattering spectroscopy; gold nanorod; plasmonic nanostructure

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