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Biomarkers. 2017 May - Jun;22(3-4):361-366. doi: 10.1080/1354750X.2016.1276966. Epub 2017 Jan 25.

Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study.

Author information

1
a Department of Public Health, Campbell University College of Pharmacy and Health Sciences , Campbell University , Buies Creek , NC , United States.
2
b Department of Epidemiology & Population Health, School of Public Health and Information Sciences , University of Louisville , Louisville , KY , United States.
3
c Department of Medicine and Family and Preventive Medicine , University of California San Diego , La Jolla , United States.
4
d Department of Epidemiology and Population Health , Yeshiva University Albert Einstein College of Medicine , Bronx , United States.
5
e Harvard Medical School , Boston , United States.
6
f Departments of Pathology and Biochemistry , University of Vermont College of Medicine , Burlington , United States.
7
g Department of Geriatric Medicine , University of Pittsburgh , Pittsburgh , United States.
8
h Senior Vice President for Research, New York Academy of Medicine , New York , United States.
9
i Deparment of Internal Medicine , University of California Berkeley , Berkeley , United States.
10
j Deparment of General Medicine and Primary Care , Beth Israel Deaconess Medical Center , Boston , United States.

Abstract

CONTEXT:

Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease.

OBJECTIVE:

The objective of this study is to investigate the association between sleep-disordered breathing (SDB) - a source of oxidative stress - and CML.

MATERIALS AND METHODS:

About 1002 participants in the Cardiovascular Health Study (CHS) were studied.

RESULTS:

Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03-2.58, p = 0.04). The association was not significant among men.

DISCUSSION:

SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study.

CONCLUSION:

Accumulation of CML may be an adverse health consequence of SDB.

KEYWORDS:

Apnea–Hypopnea Index; Carboxymethyl-lysine; advanced glycation end-product; oxidative stress; sleep-disordered breathing

PMID:
28055285
PMCID:
PMC5572083
DOI:
10.1080/1354750X.2016.1276966
[Indexed for MEDLINE]
Free PMC Article

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