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Wounds. 2017 Mar;29(3):80-86. Epub 2016 Dec 29.

Evaluation of Honey as a Topical Therapy for Intraoral Wound Healing in Rats.

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Department of Oral Medicine, Dental School, Kerman University of Medical Sciences, Kerman, Iran.
Department of Pharmacognosy, School of Pharmacy, Kerman University of Medical Sciences.
Department of Genetic and Molecular Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Persian Literature and English Language, School of Medicine, Hamadan University of Medical Sciences.
Dental Research Center and Research Center for Molecular Medicine, Department of Oral Medicine, Dental School, Hamadan University of Medical Sciences.



Honey is one of the oldest known medicines. Its medical and therapeutic importance has been recently rediscovered. Honey is an effective treatment for infected wounds and ulcers. The aim of this study was to determine the effect of honey as a topical therapy for intraoral wound healing in rats.


Thirty-two male rats were divided into experimental and control groups (consisting of 16 rats, 4 animals in each group). A 2-mm mucosal defect was made to the depth of the periosteum using punch biopsy. Honey was applied to the wound every day, and the ulcer size was measured daily. On days 2, 4, 6, and 8, four rats were euthanized from each group (experimental and control groups), and tissues were histopathologically evaluated. Healing processes were studied as follows: the size of ulcer, inflammatory response, reepithelialization, and granulation tissue formation.


The mean rank of wound size was significantly reduced in the honey group (2.50), as compared to the control group (6.50). Reepithelialization and granulation tissue formation mean rank were significantly higher in the honey group (6.50) than in the control group (2.50). Inflammation mean rank was statistically lower in the honey group (2.63) compared with the control group (6.38).


Honey was shown to have a beneficial effect on the healing of oral ulcers in rats in this model. Further research may shed light on the effects of honey on different types of ulcers in humans.

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