Format

Send to

Choose Destination
Adv Mater. 2017 Mar;29(10). doi: 10.1002/adma.201603997. Epub 2017 Jan 5.

Nanopolymersomes with an Ultrahigh Iodine Content for High-Performance X-Ray Computed Tomography Imaging In Vivo.

Author information

1
Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P.R. China.
2
Department of Biomaterials Science and Technology, MIRA Institute for Biological Technology and Technical Medicine, University of Twente, PO Box 217, 7500AE, Enschede, The Netherlands.
3
Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences, Soochow University, Suzhou, 215123, P.R. China.

Abstract

Biocompatible and biodegradable nanopolymersomes with an unprecedented iodine content, low viscosity, and iso-osmolality achieve significantly enhanced CT imaging of blood pool and the reticuloendothelial system. Moreover, in subcutaneous and orthotopic tumor models in mice, they show enhanced in vivo imaging when compared to iohexol, a clinically used small-molecule contrast agent.

KEYWORDS:

computed tomography; contrast agents; polymersomes; targeted imaging

PMID:
28054400
DOI:
10.1002/adma.201603997
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center