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ACS Nano. 2017 Jan 24;11(1):613-620. doi: 10.1021/acsnano.6b06892. Epub 2017 Jan 4.

H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery.

Author information

1
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University , Raleigh, North Carolina 27695, United States.
2
State Key Laboratory of Polymer Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Jilin, 130022, People's Republic of China.
3
Department of Medicine, University of North Carolina School of Medicine , Chapel Hill, North Carolina 27599, United States.

Abstract

A self-regulated "smart" insulin administration system would be highly desirable for diabetes management. Here, a glucose-responsive insulin delivery device, which integrates H2O2-responsive polymeric vesicles (PVs) with a transcutaneous microneedle-array patch was prepared to achieve a fast response, excellent biocompatibility, and painless administration. The PVs are self-assembled from block copolymer incorporated with polyethylene glycol (PEG) and phenylboronic ester (PBE)-conjugated polyserine (designated mPEG-b-P(Ser-PBE)) and loaded with glucose oxidase (GOx) and insulin. The polymeric vesicles function as both moieties of the glucose sensing element (GOx) and the insulin release actuator to provide basal insulin release as well as promote insulin release in response to hyperglycemic states. In the current study, insulin release responds quickly to elevated glucose and its kinetics can be modulated by adjusting the concentration of GOx loaded into the microneedles. In vivo testing indicates that a single patch can regulate glucose levels effectively with reduced risk of hypoglycemia.

KEYWORDS:

diabetes; drug delivery; glucose-responsive; insulin; polymersome; vesicles

PMID:
28051306
PMCID:
PMC5568789
DOI:
10.1021/acsnano.6b06892
[Indexed for MEDLINE]
Free PMC Article

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