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J Neurogastroenterol Motil. 2017 Jan 30;23(1):9-19. doi: 10.5056/jnm16124.

Therapeutic Modulation of Gut Microbiota in Functional Bowel Disorders.

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  • 1Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 2Department of Internal Medicine, National Medical Center, Seoul, Korea.
  • 3Department of Internal Medicine, Wonkwang University College of Medicine and Digestive Disease Research Institute, Iksan, Korea.
  • 4Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
  • 5Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
  • 6Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 7Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.


Functional bowel disorders (FBDs) are functional gastrointestinal disorders with symptoms attributable to the middle or lower gastrointestinal tract. These include irritable bowel syndrome, functional bloating, functional constipation, functional diarrhea, and unspecified FBD. Increasing evidence has emerged of late that intestinal microbiota is involved in the pathogenesis of FBDs. In this review, the therapeutic benefits and future perspectives of the currently available strategies for modifying the gut microbiota in FBDs are described, focusing primarily on irritable bowel syndrome and functional constipation.


Diet; Fecal microbiota transplantation; Irritable bowel syndrome; Microbiota; Probiotics


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