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FASEB J. 2017 Jan;31(1):333-345. doi: 10.1096/fj.201600459RR. Epub 2016 Oct 20.

Rutin ameliorates obesity through brown fat activation.

Yuan X1,2, Wei G1,2, You Y3, Huang Y1,2, Lee HJ1, Dong M1,2, Lin J1,2, Hu T1,2, Zhang H1, Zhang C1, Zhou H1,2, Ye R1,2, Qi X2,4, Zhai B3, Huang W3, Liu S5, Xie W5, Liu Q6, Liu X7, Cui C8, Li D8, Zhan J3, Cheng J5, Yuan Z9,4, Jin W10.

Author information

1
Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
2
The University of the Chinese Academy of Sciences, Beijing, China.
3
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
4
State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
5
Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
6
High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China.
7
College of Life Sciences, Zhoukou Normal University, Henan, China; and.
8
Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University, Yanji, China.
9
The University of the Chinese Academy of Sciences, Beijing, China; zqyuan@ibp.ac.cn.
10
Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; jinw@ioz.ac.cn.

Abstract

Increasing energy expenditure through activation of brown adipose tissue (BAT) is a critical approach to treating obesity and diabetes. In this study, rutin, a natural compound extracted from mulberry and a drug used as a capillary stabilizer clinically for many years without any side effects, regulated whole-body energy metabolism by enhancing BAT activity. Rutin treatment significantly reduced adiposity, increased energy expenditure, and improved glucose homeostasis in both genetically obese (Db/Db) and diet-induced obesity (DIO) mice. Rutin also induced brown-like adipocyte (beige) formation in subcutaneous adipose tissue in both obesity mouse models. Mechanistically, we found that rutin directly bound to and stabilized SIRT1, leading to hypoacetylation of peroxisome proliferator-activated receptor γ coactivator-1α protein, which stimulated Tfam transactivation and eventually augmented the number of mitochondria and UCP1 activity in BAT. These findings reveal that rutin is a novel small molecule that activates BAT and may provide a novel therapeutic approach to the treatment of metabolic disorders.-Yuan, X., Wei, G., You, Y., Huang, Y., Lee, H. J., Dong, M., Lin, J., Hu, T., Zhang, H., Zhang, C., Zhou, H., Ye, R., Qi, X., Zhai, B., Huang, W., Liu, S., Xie, W., Liu, Q., Liu, X., Cui, C., Li, D., Zhan, J., Cheng, J., Yuan, Z., Jin, W. Rutin ameliorates obesity through brown fat activation.

KEYWORDS:

brown adipose tissue; energy expenditure; mitochondria; obesity; rutin

PMID:
28049156
DOI:
10.1096/fj.201600459RR
[Indexed for MEDLINE]

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