Format

Send to

Choose Destination
See comment in PubMed Commons below
Can J Neurol Sci. 1989 Nov;16(4):426-31.

Chorea-acanthocytosis: report of a family and neuropathological study of two cases.

Author information

1
Department of Genetics, National Institute of Neurology and Neurosurgery, Mexico, D.F.

Abstract

We report three siblings, offspring of normal consanguineous parents, with a progressive neurological illness that began in midlife and was characterized primarily by chorea and leading to death in the fourth decade. The proband had erythrocyte acanthocytosis with normal serum beta-lipoprotein. Biopsy of left gastrocnemius muscle showed neurogenic muscular atrophy. There was a decrease in the numbers of large myelinated axons of the sural nerve. Postmortem examination of two cases showed marked atrophy, neuronal loss and gliosis of the caudate nucleus and putamen. Autosomal recessive inheritance is likely in this family.

PMID:
2804805
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center