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Brain Res. 1989 Sep 4;496(1-2):357-60.

Characteristics of the bursting pattern of action potentials that occurs in the thalamus of patients with central pain.

Author information

1
Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21205.

Abstract

Neurons in the somatosensory thalamus of patients with central pain following spinal cord injury fire in bursts of action potentials more frequently than do similar neurons in patients without pain. Furthermore, the characteristic firing pattern within these bursts is similar to that which is shown to be associated with the occurrence of calcium spikes in intracellular studies of thalamic nuclei. This finding may have significant implications for the etiology and treatment of central pain states.

PMID:
2804648
DOI:
10.1016/0006-8993(89)91088-3
[Indexed for MEDLINE]

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