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PLoS One. 2017 Jan 3;12(1):e0169252. doi: 10.1371/journal.pone.0169252. eCollection 2017.

Feasibility Study on Applying Radiophotoluminescent Glass Dosimeters for CyberKnife SRS Dose Verification.

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Medical Physics and Radiation Measurements Laboratory, Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC.
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC.
Biophotonics and Molecular Imaging Research Center, National Yang-Ming University, Taipei, Taiwan, ROC.
Division of Radiation Therapy and Oncology, Chang Gung Memorial Hospital, Chia-Yi, Taiwan, ROC.
School of Medical Laboratory Science and Biotechnology, Collage of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, ROC.
Department of radiation Oncology, MacKay Memorial Hospital, New-Taipei, Taiwan, ROC.
CyberKnife Treatment Center, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan, ROC.
Department of Medical Imaging and Radiological Sciences, I-Shou University, Taiwan, R.O.C.
Medical Physics Graduate Program at Duke Kunshan University, Kunshan, Jiangsu, China.


CyberKnife is one of multiple modalities for stereotactic radiosurgery (SRS). Due to the nature of CyberKnife and the characteristics of SRS, dose evaluation of the CyberKnife procedure is critical. A radiophotoluminescent glass dosimeter was used to verify the dose accuracy for the CyberKnife procedure and validate a viable dose verification system for CyberKnife treatment. A radiophotoluminescent glass dosimeter, thermoluminescent dosimeter, and Kodak EDR2 film were used to measure the lateral dose profile and percent depth dose of CyberKnife. A Monte Carlo simulation for dose verification was performed using BEAMnrc to verify the measured results. This study also used a radiophotoluminescent glass dosimeter coupled with an anthropomorphic phantom to evaluate the accuracy of the dose given by CyberKnife. Measurements from the radiophotoluminescent glass dosimeter were compared with the results of a thermoluminescent dosimeter and EDR2 film, and the differences found were less than 5%. The radiophotoluminescent glass dosimeter has some advantages in terms of dose measurements over CyberKnife, such as repeatability, stability, and small effective size. These advantages make radiophotoluminescent glass dosimeters a potential candidate dosimeter for the CyberKnife procedure. This study concludes that radiophotoluminescent glass dosimeters are a promising and reliable dosimeter for CyberKnife dose verification with clinically acceptable accuracy within 5%.

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