Format

Send to

Choose Destination
Cancer Biol Ther. 2017 Apr 3;18(4):257-267. doi: 10.1080/15384047.2016.1276130. Epub 2017 Jan 3.

Dietary selenium protects adiponectin knockout mice against chronic inflammation induced colon cancer.

Author information

1
a Department of Exercise Science , Arnold School of Public Health, University of South Carolina , Columbia , SC , USA.
2
b Center for Colon Cancer Research, University of South Carolina , Columbia , SC , USA.
3
c Department of Environmental Health Science , Arnold School of Public Health, University of South Carolina , Columbia , SC , USA.

Abstract

Selenium (Se) is an essential dietary micronutrient that has been examined for protection against different types of cancers including colon cancer. Despite an established inverse association between Se and chronic inflammation induced colon cancer (CICC), the mechanistic understanding of Se's protective effects requires additional in-vivo studies using preclinical animal models of CICC. Adiponectin (APN) is an adipocytokine that is protective against CICC as well. However, its role in the anti-mutagenic effects of the Se-diet remains unknown. To address this knowledge gap, here we examine the ability of dietary Se in reducing CICC in APN knockout mice (KO) and its wild-type C57BL/6. CICC was induced with the colon cancer agent 1,2 dimethyl hydrazine (DMH) along with dextran sodium sulfate (DSS). Se-enhanced diet increased selenoproteins, Gpx-1 and Gpx-2, in the colon tissues, thereby reducing oxidative stress. Se-mediated reduction of CICC was evident from the histopathological studies in both mouse models. In both mice, reduction in inflammation and tumorigenesis associated well with reduced p65 phosphorylation and elevated 53 phosphorylation. Finally, we show that in both models Se-administration promotes goblet cell differentiation with a concomitant increase in the levels of associated proteins, Muc-2 and Math-1. Our findings suggest that Se's protection against CICC involves both colonic epithelial protection and anti-tumor effects that are independent of APN.

KEYWORDS:

Adiponectin; chronic inflammation; colon cancer; goblet cell differentiation; selenium

PMID:
28045589
PMCID:
PMC5450735
DOI:
10.1080/15384047.2016.1276130
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center