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Hum Brain Mapp. 2017 Mar;38(3):1659-1675. doi: 10.1002/hbm.23488. Epub 2017 Jan 3.

Correspondent Functional Topography of the Human Left Inferior Parietal Lobule at Rest and Under Task Revealed Using Resting-State fMRI and Coactivation Based Parcellation.

Wang J1, Xie S2,3, Guo X1, Becker B1, Fox PT4, Eickhoff SB5,6, Jiang T1,2,3,7,8.

Author information

1
Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 625014, China.
2
Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
3
National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
4
Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
5
Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
6
Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Dusseldorf, Germany.
7
CAS Center for Excellence in Brain Science, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
8
The Queensland Brain Institute, University of Queensland, Brisbane, Queensland, 4072, Australia.

Abstract

The human left inferior parietal lobule (LIPL) plays a pivotal role in many cognitive functions and is an important node in the default mode network (DMN). Although many previous studies have proposed different parcellation schemes for the LIPL, the detailed functional organization of the LIPL and the exact correspondence between the DMN and LIPL subregions remain unclear. Mounting evidence indicates that spontaneous fluctuations in the brain are strongly associated with cognitive performance at the behavioral level. However, whether a consistent functional topographic organization of the LIPL during rest and under task can be revealed remains unknown. Here, they used resting-state functional connectivity (RSFC) and task-related coactivation patterns separately to parcellate the LIPL and identified seven subregions. Four subregions were located in the supramarginal gyrus (SMG) and three subregions were located in the angular gyrus (AG). The subregion-specific networks and functional characterization revealed that the four anterior subregions were found to be primarily involved in sensorimotor processing, movement imagination and inhibitory control, audition perception and speech processing, and social cognition, whereas the three posterior subregions were mainly involved in episodic memory, semantic processing, and spatial cognition. The results revealed a detailed functional organization of the LIPL and suggested that the LIPL is a functionally heterogeneous area. In addition, the present study demonstrated that the functional architecture of the LIPL during rest corresponds with that found in task processing. Hum Brain Mapp 38:1659-1675, 2017.

KEYWORDS:

coactivation; correspondent functional topography; left inferior parietal lobule; parcellation; resting-state

PMID:
28045222
DOI:
10.1002/hbm.23488
[Indexed for MEDLINE]

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