Format

Send to

Choose Destination
J Cell Biol. 2017 Feb;216(2):305-315. doi: 10.1083/jcb.201610042. Epub 2017 Jan 2.

Mechanosensing by the nucleus: From pathways to scaling relationships.

Author information

1
Molecular and Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA 19104.
2
Molecular and Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA 19104 discher@seas.upenn.edu.

Abstract

The nucleus is linked mechanically to the extracellular matrix via multiple polymers that transmit forces to the nuclear envelope and into the nuclear interior. Here, we review some of the emerging mechanisms of nuclear mechanosensing, which range from changes in protein conformation and transcription factor localization to chromosome reorganization and membrane dilation up to rupture. Nuclear mechanosensing encompasses biophysically complex pathways that often converge on the main structural proteins of the nucleus, the lamins. We also perform meta-analyses of public transcriptomics and proteomics data, which indicate that some of the mechanosensing pathways relaying signals from the collagen matrix to the nucleus apply to a broad range of species, tissues, and diseases.

PMID:
28043971
PMCID:
PMC5294790
DOI:
10.1083/jcb.201610042
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center