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Am J Hum Genet. 2017 Jan 5;100(1):64-74. doi: 10.1016/j.ajhg.2016.11.013. Epub 2016 Dec 29.

A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis.

Author information

1
Instituto de Parasitología y Biomedicina "López-Neyra," CSIC, PTS Granada, Granada 18016, Spain; Departamento de Genética e Instituto de Biotecnología, Universidad de Granada, Granada 18016, Spain. Electronic address: dcarmona@ipb.csic.es.
2
Unit of Nephrology, University Hospital of Parma, Parma 43126, Italy.
3
School of Medicine, University of Leeds and NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds LS7 4SA, UK.
4
Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain.
5
Section of Rheumatology, Boston University, Boston, MA 02118, USA.
6
Department of Rheumatology, Hospital de la Princesa, IIS-IP, Madrid 28006, Spain.
7
Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona 08035, Spain.
8
Department of Rheumatology, Hospital Clínico San Carlos, Madrid 28040, Spain.
9
Department of Rheumatology, Hospital Universitario de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Barcelona 08907, Spain.
10
Department of Rheumatology, Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea SS0 0RY, UK.
11
Department of Rheumatology, Ipswich Hospital NHS Trust, Ipswich IP4 5PD, UK.
12
Division of Rheumatology, McMaster University, Hamilton, ON L8N 1Y2, Canada.
13
Division of Rheumatology, Cleveland Clinic, Cleveland, OH 44195, USA.
14
Division of Rheumatology, Mayo Clinic, Rochester, MN 55905, USA.
15
Rheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia 42123, Italy.
16
Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan 20122, Italy.
17
Department of Rheumatology, Azienda Ospedaliero Universitaria S. Anna, University of Ferrara, Ferrara 44121, Italy.
18
Department of Experimental and Clinical Medicine, University of Florence, Florence 50134, Italy.
19
Department of Clinical and Experimental Medicine, Medical Genetics Unit, University of Parma, Parma 43124, Italy.
20
Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova 16132, Italy.
21
Hannover Medical School, Hannover 30625, Germany.
22
Klinik für Innere Medizin III, University-Hospital Jena, Jena 07743, Germany.
23
Vasculitis Clinic, Klinikum Bad Bramstedt & University Hospital of Schleswig Holstein, Bad Bramstedt 24576, Germany.
24
Department of Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen 91054, Germany.
25
Service de Médecine Interne, Hopital de Purpan, CHU de Toulouse, UMR 1027, INSERM, Universite de Toulouse, Toulouse 31059, France.
26
Service de Médecine Interne, Hôpital Bichat, Université Paris-Diderot, Paris 75018, France.
27
Department of Internal Medicine & French Reference Center for Rare Auto-immune & Systemic Diseases, Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié-Salpêtrière Hospital, Paris 75013, France.
28
Department of Internal Medicine, Hospital Saint-Louis ECSTRA Team, Epidemiology and Biostatistics, Sorbonne Paris Cité Research Center UMR 1153, Inserm, University Paris Diderot, Paris 75010, France.
29
Department of Internal Medicine, Cochin Hospital, National Referral Center for Rare Autoimmune and Systemic Diseases, AP-HP, Université Paris Descartes, Paris 75014, France.
30
Department of Rheumatology, Oslo University Hospital, Oslo 0424, Norway.
31
Department of Rheumatology, Hospital of Southern Norway Trust, Kristiansand 4604, Norway.
32
Amsterdam Rheumatology and Immunology Center, VU University Medical Center, Amsterdam 1007 MB, the Netherlands.
33
Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, Netherlands.
34
Rheumatology Department of Internal Medicine, University Hospital, Basel 4056, Switzerland.
35
Translational Immunology and Medical Outpatient Clinic, Departments of Biomedicine and Internal Medicine, University Hospital, Basel 4056, Switzerland.
36
Department of Rheumatology, Centre for Arthritis and Rheumatic Diseases, St Vincent's University Hospital, Dublin Academic Medical Centre, Dublin 4, Ireland.
37
Department of General Internal Medicine, University Hospital Gasthuisberg, Leuven 3000, Belgium.
38
Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo 0450, Norway.
39
Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.
40
Divisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Disease, King's College London, London SE1 9RT, UK.
41
Department of Genetics, University Medical Center Groningen, Groningen 9713 AV, the Netherlands.
42
Paris Descartes University, Rheumatology A department, Sorbonne Paris Cité, Cochin Hospital, Paris 75014, France.
43
Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584 CX, the Netherlands.
44
Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA 19104, USA.
45
Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander 39008, Spain.
46
Instituto de Parasitología y Biomedicina "López-Neyra," CSIC, PTS Granada, Granada 18016, Spain.

Abstract

Giant cell arteritis (GCA) is the most common form of vasculitis in individuals older than 50 years in Western countries. To shed light onto the genetic background influencing susceptibility for GCA, we performed a genome-wide association screening in a well-powered study cohort. After imputation, 1,844,133 genetic variants were analyzed in 2,134 case subjects and 9,125 unaffected individuals from ten independent populations of European ancestry. Our data confirmed HLA class II as the strongest associated region (independent signals: rs9268905, p = 1.94 × 10-54, per-allele OR = 1.79; and rs9275592, p = 1.14 × 10-40, OR = 2.08). Additionally, PLG and P4HA2 were identified as GCA risk genes at the genome-wide level of significance (rs4252134, p = 1.23 × 10-10, OR = 1.28; and rs128738, p = 4.60 × 10-9, OR = 1.32, respectively). Interestingly, we observed that the association peaks overlapped with different regulatory elements related to cell types and tissues involved in the pathophysiology of GCA. PLG and P4HA2 are involved in vascular remodelling and angiogenesis, suggesting a high relevance of these processes for the pathogenic mechanisms underlying this type of vasculitis.

PMID:
28041642
PMCID:
PMC5223025
DOI:
10.1016/j.ajhg.2016.11.013
[Indexed for MEDLINE]
Free PMC Article

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