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Maturitas. 2017 Feb;96:77-83. doi: 10.1016/j.maturitas.2016.11.016. Epub 2016 Nov 27.

Influence of equol and resveratrol supplementation on health-related quality of life in menopausal women: A randomized, placebo-controlled study.

Author information

1
Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy. Electronic address: sergio.davinelli@unimol.it.
2
Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy.
3
Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
4
Farcoderm S.r.l., San Martino Siccomario, Pavia, Italy.
5
Department of Translational Medical Sciences, University of Naples "Federico II", Naples, Italy.

Abstract

OBJECTIVE:

This study was designed to evaluate the effects of equol and resveratrol supplementation on health-related quality of life (HRQoL) in otherwise healthy menopausal women with hot flashes, anxiety and depressive symptoms.

METHODS:

Sixty recently menopausal women aged 50-55 years were randomized in a 12-week, placebo-controlled trial to receive 200mg of fermented soy containing 10mg of equol and 25mg of resveratrol (1 tablet/day). The primary outcome was the change in score on the Menopause Rating Scale (MRS), used to evaluate the severity of age-/menopause-related complaints. Additional outcome measures included the subject-reported score on the Hamilton Rating Scale for Depression (HAM-D) and Nottingham Health Profile (NHP), which was used specifically to assess sleep quality.

RESULTS:

The symptoms assessed by the MRS improved during treatment in the active group. Comparison between placebo and treatment groups revealed statistically significant improvement in particular for dryness of vagina (-85.7%) (p<0.001), heart discomfort (-78.8%; p<0.001) and sexual problems (-73.3%; p<0.001). On the HAM-D significant improvements at week 12 were seen in work and activities (-94.1%) (p<0.001). Subjects treated with equol and resveratrol also had significant differences in the sleep domain of the NHP (p<0.001).

CONCLUSION:

These findings provide evidence that 12 weeks of dietary supplementation with equol and resveratrol may improve menopause-related quality of life in healthy women.

KEYWORDS:

Equol; Menopause; Phytoestrogens; Resveratrol

PMID:
28041599
DOI:
10.1016/j.maturitas.2016.11.016
[Indexed for MEDLINE]

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