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Maturitas. 2017 Feb;96:58-71. doi: 10.1016/j.maturitas.2016.11.012. Epub 2016 Nov 19.

The effects of vitamin B on the immune/cytokine network and their involvement in depression.

Author information

1
Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, PO Box 14426, Melbourne, VIC 8001, Australia.
2
Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, PO Box 14426, Melbourne, VIC 8001, Australia. Electronic address: vasso.apostolopoulos@vu.edu.au.

Abstract

Increasing evidence indicates that there are various interactions between the nervous system and the immune system, and that the immune system plays an important role in the pathogenesis of depression. Pro-inflammatory cytokines (such as IL-1, IL-6, TNF-α) have been implicated in the neurobiological manifestations of depression. The immune/cytokine network has a powerful influence on the brain. In addition, deficiency in B vitamins has been linked to depression. Hence, greater knowledge of how immune cells change in the presence of vitamin B derivatives could improve understanding of how immune changes may correlate with depression, all of which are discussed herein.

KEYWORDS:

Depression; Immune cells; Immune system; Inflammation; Mental health

PMID:
28041597
DOI:
10.1016/j.maturitas.2016.11.012
[Indexed for MEDLINE]

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