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Presse Med. 2017 Mar;46(2 Pt 1):159-164. doi: 10.1016/j.lpm.2016.11.005. Epub 2016 Dec 28.

[Effect of drugs for osteoporosis on cardiovascular diseases and effect of cardio vascular drugs on osteoporosis].

[Article in French]

Author information

1
CHU Purpan, hôpital Pierre-Paul-Riquet, centre de rhumatologie, 1, place du Dr-Baylac, 31059 Toulouse cedex, France. Electronic address: laroche.m@chu-toulouse.fr.
2
CHU Purpan, hôpital Pierre-Paul-Riquet, centre de rhumatologie, 1, place du Dr-Baylac, 31059 Toulouse cedex, France.

Abstract

Osteoporosis and cardiovascular diseases are epidemiologically associated. Calcification phenomena of atherosclerotic plaque involve cytokines and growth factors also involved in bone remodeling. Drugs given for either of these two conditions could act on these mechanisms. Can osteoporosis drugs have an influence on the occurrence of cardiovascular events? Conversely, can the treatment of hypertension alter the course of osteoporosis? It is possible that administration of high doses of calcium (1g/day) in patients who already have important dietary intake can increase the risk of myocardial infarction. Epidemiological studies show links between low serum vitamin D levels and cardiovascular disease but interventional studies show that vitamin D administration in moderately deficient subjects vitamin D does not prevent the occurrence of cardiovascular events. Cohort studies show a beneficial effect of beta-blockers and thiazides administered to hypertensive patients: they reduce by 20% risk of fracture of the proximal femur. Should we focus on these anti-hypertensive treatments for our patients with osteoporosis?

PMID:
28040349
DOI:
10.1016/j.lpm.2016.11.005
[Indexed for MEDLINE]

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