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Fertil Steril. 2017 Jan;107(1):4-5. doi: 10.1016/j.fertnstert.2016.11.017.

Introduction: Subchromosomal abnormalities in preimplantation embryonic aneuploidy screening.

Author information

1
Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey. Electronic address: rscott@rmanj.com.

Abstract

The application of next generation sequencing platforms for embryonic aneuploidy screening provides enhanced resolution that allows routine evaluation of subchromosomal copy number abnormalities and mosaicism. Approximately 20% of embryos that would be designated as euploid using the conventional 24-chromosome aneuploidy screening will have evidence of a subchromosomal abnormality or mosaicism. This new information brings many challenges. Understanding the impact of these abnormalities on implantation and delivery rates is key to optimizing clinical counseling and management.

KEYWORDS:

Chromosomal duplications; chromosomal deletions; embryonic mosaicism; preimplantation genetic screening; subchromosomal defects

[Indexed for MEDLINE]

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