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Support Care Cancer. 2016 Dec 30. doi: 10.1007/s00520-016-3530-6. [Epub ahead of print]

Factors supporting cardiomyopathy screening among at-risk adult survivors of pediatric malignancies.

Author information

  • 1Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-2794, USA. cox1072@bellsouth.net.
  • 2Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • 3Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-2794, USA.
  • 4Department of Anesthesia, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • 5Department of Nursing Research, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • 6Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Abstract

PURPOSE:

Anthracyclines and chest irradiation place adult survivors of childhood cancer at risk of cardiomyopathy; many survivors do not obtain the recommended screening. Based on our recent clinical trial, the addition of telephone counseling to a printed survivorship care plan more than doubled survivors' risk-based screening. Here, we sought to measure the impact of specific factors targeted in the intervention for their impact on survivors' screening participation.

METHODS:

Study population-survivors participating in a randomized longitudinal intervention trial. Survivor questionnaires and medical records at baseline and 1-year follow-up provided the data. Within- and between-group differences in factors were assessed at baseline and follow-up; structural equation modeling (SEM) identified direct and indirect effects on screening participation.

RESULTS:

Of the 411 survivors, 55.3% were female, 89.3% white, 38.9% college graduates, and age 26-59 years (mean = 41 years, SD = 7.68 years). At follow-up, the counseling group demonstrated higher scores for intent to undergo screening (p < 0.001), adherence determination (p < 0.001), autonomous regulation (p < 0.001), competency (p = 0.03), perceived effort warranted for screening (p < 0.001), and perceived value of screening (p = 0.02). SEM identified four factors that directly influenced screening participation (n = 411, RMSEA = 0.02 [90% CI = 0.000-0.05]; CFI = 0.99; TLI = 0.99; WRMR = 0.63): the counseling intervention (p < 0.0001), intrinsic motivation (p < 0.0001), competency (p < 0.0001), and decisional control (p = 0.001); intrinsic motivation was also a mediator (p = 0.002) of screening participation.

CONCLUSIONS:

Direct interpersonal interaction that focused on multiple modifiable, autonomy-supportive factors powerfully enhances the efficacy of a print survivorship care plan in increasing survivors' screening participation. This finding challenges providers to reach beyond the disease treatment focus and embrace these strategies in their behavior change efforts.

KEYWORDS:

Cardiomyopathy; Echocardiogram; Late effects; Pediatric cancer; Survivors

PMID:
28039505
DOI:
10.1007/s00520-016-3530-6
[PubMed - as supplied by publisher]
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