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Mol Biol Evol. 2017 Mar 1;34(3):634-639. doi: 10.1093/molbev/msw262.

An Intact Retroviral Gene Conserved in Spiny-Rayed Fishes for over 100 My.

Author information

1
Biology Department, Boston College, Chestnut Hill, MA.
2
MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.

Abstract

We have identified a retroviral envelope gene with a complete, intact open reading frame (ORF) in 20 species of spiny-rayed fishes (Acanthomorpha). The taxonomic distribution of the gene, "percomORF", indicates insertion into the ancestral lineage >110 Ma, making it the oldest known conserved gene of viral origin in a vertebrate genome. Underscoring its ancient provenence, percomORF exists as an isolated ORF within the intron of a widely conserved host gene, with no discernible proviral sequence nearby. Despite its remarkable age, percomORF retains canonical features of a retroviral glycoprotein, and tests for selection strongly suggest cooption for a host function. Retroviral envelope genes have been coopted for a role in placentogenesis by numerous lineages of mammals, including eutherians and marsupials, representing a variety of placental structures. Therefore percomORF's presence within the group Percomorpha-unique among spiny-finned fishes in having evolved placentation and live birth-is especially intriguing.

KEYWORDS:

endogenous retrovirus; evolution.; viral gene cooption

PMID:
28039384
PMCID:
PMC5939848
DOI:
10.1093/molbev/msw262
[Indexed for MEDLINE]
Free PMC Article

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