Format

Send to

Choose Destination
Bioinformatics. 2017 Mar 15;33(6):923-925. doi: 10.1093/bioinformatics/btw736.

AltORFev facilitates the prediction of alternative open reading frames in eukaryotic mRNAs.

Author information

1
Institute of Cytology & Genetics, SB RAS, Novosibirsk, Russia.
2
Novosibirsk State University, Novosibirsk, Russia.
3
Molecular Biology and Genetics, Izmir Institute of Technologies, Izmir, Turkey.

Abstract

Motivation:

Protein synthesis is not a straight forward process and one gene locus can produce many isoforms, for example, by starting mRNA translation from alternative start sites. altORF evaluator (altORFev) predicts alternative open reading frames within eukaryotic mRNA translated by a linear scanning mechanism and its modifications (leaky scanning and reinitiation). The program reveals the efficiently translated altORFs recognized by the majority of 40S ribosomal subunits landing on the 5'-end of an mRNA. This information aids to reveal the functions of eukaryotic genes connected to synthesis of either unknown isoforms of annotated proteins or new unrelated polypeptides.

Availability and Implementation:

altORFev is available at http://www.bionet.nsc.ru/AUGWeb/ and has been developed in Java 1.8 using the BioJava library; and the Vaadin framework to produce the web service.

Contact:

ak@bionet.nsc.ru.

PMID:
28039164
DOI:
10.1093/bioinformatics/btw736
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center