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Microb Pathog. 2017 Feb;103:155-161. doi: 10.1016/j.micpath.2016.12.024. Epub 2016 Dec 27.

DNAzymes Dz13 target the c-jun possess antiviral activity against influenza A viruses.

Author information

1
Henan Institute of Science and Technology, Xinxiang 453003, China.
2
Henan Institute of Science and Technology, Xinxiang 453003, China; Postdoctoral Research Base, Henan Institute of Science and Technology, Xinxiang 453003, China; Post-doctoral Research Station, Henan Agriculture University, Zhengzhou 450002, China.
3
Henan Institute of Science and Technology, Xinxiang 453003, China. Electronic address: wangsanhu@hist.edu.cn.

Abstract

The emergence of anti-influenza A virus drugs resistant strain highlights the need for more effective therapy. Our earlier study demonstrated that c-jun, a downstream molecule of JNK, might be important in viral infections and inflammatory responses. In the present study, we explored the function of DNAzymes Dz13 that target c-jun in influenza A virus infected mice. Dz13 displayed non-toxic side effects on A549 cells and BALB/c mice. Moreover, Dz13-treated mice had enhanced survival after influenza compared with untreated mice. Simultaneously, the pulmonary inflammatory responses and viral burden were decreased in Dz13 treated mice. Furthermore, proliferation levels of infection-induced CD4+ and CD8+ T cells were impaired. These data demonstrated that Dz13 could reduce viral replication and inflammatory response in vivo, suggesting that Dz13 may potentially be used to treat influenza A viral infection.

KEYWORDS:

Antiviral; C-jun; Dz13; Influenza A virus

PMID:
28039102
DOI:
10.1016/j.micpath.2016.12.024
[Indexed for MEDLINE]

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