Format

Send to

Choose Destination
See comment in PubMed Commons below
J Stroke Cerebrovasc Dis. 2017 Mar;26(3):673-676. doi: 10.1016/j.jstrokecerebrovasdis.2016.11.125. Epub 2016 Dec 27.

Herbal Supplements Association with Reversible Cerebral Vasoconstriction Syndrome: A Case Report.

Author information

1
Internal Medicine Department, Hospital Egas Moniz-Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.
2
Neurology Department, Hospital Egas Moniz-Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal; CEDOC, Nova Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal. Electronic address: marcelomendoncasousa@gmail.com.
3
Neuroimaging Department, Hospital Egas Moniz-Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.
4
Neurology Department, Hospital Egas Moniz-Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal; CEDOC, Nova Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.

Abstract

BACKGROUND:

Reversible cerebral vasoconstriction syndrome (RCVS) is a clinico-radiologic syndrome characterized by thunderclap headache and reversible multifocal arterial constrictions that resolves within 3 months. RCVS can be either spontaneous or related to a trigger; vasoactive drugs including over-the-counter medicine are common culprits. Nevertheless, there are sparse data on the association of herbal supplements in the genesis of unexplained RCVS.

METHODS:

We describe a case of RCVS with a temporal association with the consumption of a diet pill composed of green tea, L-carnitine, and conjugated linoleic acid. We reviewed the literature describing RCVS cases associated with consumption of herbal supplements or plants.

RESULTS:

A 50-year-old black woman presented at the emergency room with a thunderclap headache less than 1 week after beginning a new herbal supplement with weight loss purpose. Angiographic study revealed multiple arterial constriction of virtually all intracranial territories that were reversed 28 days later. The patient was discharged with minimal symptoms. From our review, we identified 5 previous reports of herbal product-related triggers.

CONCLUSIONS:

Different factors can trigger RCVS. Besides our case, at least 5 other nutraceutical products were described to be associated with the disorders, 3 of them in patients without any other clear cause. Clinicians should be aware of the possible role of herbal supplements in RCVS, and their use should be systematically assessed in large RCVS cohorts to clarify this association.

KEYWORDS:

RCVS; Reversible cerebral vasoconstriction syndrome; herbal supplements; nutraceuticals; triggers

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center