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Trends Neurosci. 2017 Jan;40(1):1-3. doi: 10.1016/j.tins.2016.11.003. Epub 2016 Dec 27.

Tooth-Matrix Biomarkers to Reconstruct Critical Periods of Brain Plasticity.

Author information

1
Department of Psychiatry, Neuroscience, and Ophthalmology, Friedman Brain Institute, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: hirofumi.morishita@mssm.edu.
2
Division of Environmental Health, Department of Environmental Medicine and Public Health, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: manish.arora@mssm.edu.

Abstract

Developmental brain plasticity involves complex, time-dependent dynamic molecular interactions that cannot be observed directly in humans. We propose that the shared evolutionary homology of teeth and the neurosensory system, and the archival nature of dentine microstructure, allows the development of 'biologic hard drives' that can characterize perinatal temporal dynamics in neuroplasticity.

KEYWORDS:

biomarker; brain plasticity; critical period; teeth

PMID:
28038829
PMCID:
PMC5215836
DOI:
10.1016/j.tins.2016.11.003
[Indexed for MEDLINE]
Free PMC Article

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