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Curr Opin Chem Biol. 2017 Apr;37:19-25. doi: 10.1016/j.cbpa.2016.11.022. Epub 2016 Dec 27.

Imine reductases (IREDs).

Author information

1
School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK.
2
York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5DD, UK.
3
School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK. Electronic address: nicholas.turner@manchester.ac.uk.

Abstract

Imine reductases (IREDs) have emerged as a valuable new set of biocatalysts for the asymmetric synthesis of optically active amines. The development of bioinformatics tools and searchable databases has led to the identification of a diverse range of new IRED biocatalysts that have been characterised and employed in different synthetic processes. This review describes the latest developments in the structural and mechanistic aspects of IREDs, together with synthetic applications of these enzymes, and identifies ongoing and future challenges in the field.

PMID:
28038349
DOI:
10.1016/j.cbpa.2016.11.022
[Indexed for MEDLINE]
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