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Int J Rheum Dis. 2018 Jan;21(1):266-270. doi: 10.1111/1756-185X.12968. Epub 2016 Dec 30.

Interleukin-4 cytokine single nucleotide polymorphisms in kawasaki disease: a case-control study and a review of knowledge.

Author information

1
Pediatric Rheumatology Research Group, Rheumatology Research Center, Tehran, Iran.
2
Department of Pediatrics, Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran.
3
Department of Pediatrics, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
4
Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
5
Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
6
Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
7
Department of Pediatrics, Vali-e-Asr Hospital, Tehran, Iran.
8
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

AIM:

Kawasaki disease (KD) is a systemic vasculitis of medium-sized arteries. High levels of interleukin 4 (IL-4) and the dominance of Th2 cytokines seem to be a key feature in the acute phase of KD. In this study, the role of IL-4 and IL-4R gene polymorphisms were investigated in Iranian children with KD.

METHODS:

Fifty-five patients with KD and 140 healthy subjects as a control group were enrolled in this study. Single nucleotide polymorphisms (SNPs) of IL-4 gene at positions -1098 (rs2243248), -590 (rs2243250) and -33 (rs2070874), as well as IL-4RA gene at position +1902 (rs180275) were assessed in patients and the control group.

RESULTS:

The C allele and CC genotype of IL-4 gene at position -590 and at position -33 had positive associations and the CT genotype at -590 was negatively associated with KD (odds ratio (95% CI) = 0.04 [0.01-0.09]). The haplotype TCC was more frequent among the patients, while the haplotypes TTT and TTC had a negative association with KD.

CONCLUSION:

IL-4 polymorphisms might be associated with KD in an Iranian population.

KEYWORDS:

cytokine; interleukin-4; kawasaki disease; single nucleotide polymorphisms

PMID:
28036156
DOI:
10.1111/1756-185X.12968
[Indexed for MEDLINE]

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