Format

Send to

Choose Destination
J Oral Pathol Med. 2017 Oct;46(9):710-716. doi: 10.1111/jop.12544. Epub 2017 Feb 7.

Semiquantifiable angiogenesis parameters in association with the malignant transformation of oral leukoplakia.

Author information

1
Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, University Medical Centre Rostock, Rostock, Germany.
2
Private Dental Practice, Mainz, Germany.
3
Private Dental Practice, Bangalore, India.
4
Head and Neck Institute, Mazumdar Shaw Cancer Center, Narayana Health, Bommasandra, Bangalore, India.
5
Department of Otorhinolaryngology, Head and Neck Surgery, Molecular Tumor Biology Laboratory, University Medical Centre Mainz, Mainz, Germany.

Abstract

BACKGROUND:

Aim of the study was to assess the role of angiogenesis in the process of malignant transformation of clinical diagnosed oral leucoplakia (OL).

MATERIALS AND METHODS:

A total of 131 histological preparations [oral leukoplakia/hyperkeratosis without dysplasia (OL; n = 49), oral leukoplakia/hyperkeratosis with mild dysplasia (OL-SIN1; n = 33), with moderate dysplasia (OL-SIN2; n = 13) and leukoplakia-derived oral squamous cell carcinoma (OL-OSCC; n = 36)] were evaluated for microvessel density (MVD), vessel diameter as well as for vascular endothelial growth factor (VEGF-A) expression. Data were compared within the groups.

RESULTS:

For MVD, there were significant differences between OL and OL-SIN 2/OL-OSCC (P < 0.05) and between OL-SIN 1 and OL-OSCC (P < 0.05). For OL-OSCC, vessel diameters were significantly increased compared with OL (P < 0.05). Expression of VEGF-A increased significantly gradually from OL-SIN 1 to OSCC (each P < 0.05). This was especially evident for lesions of the tongue when compared to the others.

CONCLUSION:

Angiogenesis increases during the transition from OL through dysplasia to OL-OSCC. In particular, OL-OSCCs of the tongue, VEGF-A expression may be used for estimation of malignant progression of OL.

KEYWORDS:

mean microvessel density; oral cancer; precancerous lesions; tumour progression; vascular endothelial growth factor

PMID:
28036153
DOI:
10.1111/jop.12544
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center