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Transpl Infect Dis. 2017 Apr;19(2). doi: 10.1111/tid.12654. Epub 2017 Feb 22.

JC polyomavirus nephropathy, a rare cause of transplant dysfunction: Case report and review of literature.

Author information

1
Department of Surgery, Albany Medical College, Albany, NY, USA.
2
Division of Surgery, Section of Transplantation, Albany Medical Center, Albany, NY, USA.
3
Division of Pathology, Albany Medical Center, Albany, NY, USA.
4
Center for Immunology and Microbial Diseases, Albany Medical College, Albany, NY, USA.
5
Department of Laboratory Medicine, University of Washington, Seattle, WA, USA.

Abstract

JC polyomavirus-associated nephropathy (JC-PVAN) is a rare but challenging cause of renal dysfunction. We report JC-PVAN in a renal allograft recipient and highlight the obstacles in definitive diagnosis of this disease entity. A deceased-donor renal transplant recipient was diagnosed with JC polyomavirus nephritis 4 years after transplantation. Immunosuppressive agents were subsequently reduced, resulting in an initial stabilization of renal function. We present this interesting case and discuss the challenges with diagnosing and treating this rare entity.

KEYWORDS:

JC virus; nephropathy; polyomavirus; renal transplant

PMID:
28036142
DOI:
10.1111/tid.12654
[Indexed for MEDLINE]

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