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Eur J Clin Invest. 2017 Feb;47(2):158-166. doi: 10.1111/eci.12721.

Study of the anti-JCV antibody levels in a Spanish multiple sclerosis cohort.

Author information

1
Neurology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
2
Hospital Universitario Virgen Macarena, Sevilla, Spain.
3
Immunology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain.
4
Hospital Universitario Quirón Salud Madrid, Madrid, Spain.

Abstract

BACKGROUND:

One of the risk factor to develop progressive multifocal leukoencephalopathy (PML) among natalizumab-treated patients is the presence and high levels of anti-JCV antibodies. Our purpose was to test the association of different clinical and demographic variables with the presence and levels of anti-JCV antibodies in a Spanish cohort of patients with multiple sclerosis (MS) during natalizumab treatment.

MATERIALS AND METHODS:

All patients with MS from two hospitals with at least one measure of the anti-JCV antibodies levels (2011-2014) were recruited, among them were two PML cases. Anti-JCV antibody levels were assessed using two-step ELISA.

RESULTS:

A total of 1061 patients (16·3% natalizumab-treated) participated in this study. The seropositivity rate of anti-JCV antibodies was 58·2%. It increased with age (Pcorrected = 0·00005) and was lower among HLA-DRB1*15:01 carriers (Pcorrected = 0·049). The two patients with PML were HLA-DRB1*15:01 carriers. We had at least three quarterly anti-JCV antibody measurements (index value) from 137 patients, whose levels did not increase during natalizumab treatment. However, 5·8% of these patients had an increase of the index value higher of one point in a maximum of 6 months, something that was more frequently observed (P = 0·054) among patients treated with immunosuppressant prior to natalizumab onset.

CONCLUSIONS:

Old age and HLA-DRB1*15:01 were the factors that influence positively and negatively, respectively, our anti-JCV antibody prevalence, although our both PML cases were HLA-DRB1*15:01carriers. Most of our patients showed a stable anti-JCV antibody index values during natalizumab treatment.

KEYWORDS:

Anti-JC virus antibodies; multiple sclerosis; natalizumab; progressive multifocal leukoencephalopathy

PMID:
28036121
DOI:
10.1111/eci.12721
[Indexed for MEDLINE]

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