The HUGE formula (hematocrit, urea, gender) for screening for chronic kidney disease in elderly patients: a study of diagnostic accuracy

Int Urol Nephrol. 2017 Apr;49(4):677-680. doi: 10.1007/s11255-016-1486-6. Epub 2016 Dec 29.

Abstract

Chronically reduced glomerular filtration rate (GFR) in old people does not always mean that they suffer from chronic kidney disease (CKD) since their GFR can just be reduced by aging. The HUGE equation has been recently described and validated in Spain for screening CKD without taking into account the patient's GFR value. This equation is based on patient's hematocrit, plasma urea levels and gender. The present study documented that the HUGE equation had and acceptable performance for screening CKD in elderly Argentine patients.

Keywords: Chronic kidney disease; Elderly; HUGE equation.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Argentina
  • False Negative Reactions
  • False Positive Reactions
  • Female
  • Glomerular Filtration Rate
  • Hematocrit*
  • Humans
  • Male
  • Mass Screening / methods*
  • Mathematical Concepts
  • Renal Insufficiency, Chronic / blood*
  • Renal Insufficiency, Chronic / diagnosis*
  • Renal Insufficiency, Chronic / physiopathology
  • Retrospective Studies
  • Sensitivity and Specificity
  • Sex Factors*
  • Urea / blood*

Substances

  • Urea