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Biochimie. 2017 May;136:3-11. doi: 10.1016/j.biochi.2016.12.012. Epub 2016 Dec 27.

Control of adipogenesis by oxylipins, GPCRs and PPARs.

Author information

1
Inserm, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, 31432, France; University of Toulouse, UMR1048, Paul Sabatier University, Toulouse, 31432, France.
2
Université Côte d'Azur, CNRS, Inserm, iBV, France.
3
Technische Universität München, Chair of Molecular Nutritional Medicine, Else Kröner-Fresenius Center, 85350, Freising-Weihenstephan, Germany.
4
Inserm, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, 31432, France; University of Toulouse, UMR1048, Paul Sabatier University, Toulouse, 31432, France; Toulouse University Hospitals, Department of Clinical Biochemistry, Toulouse, 31059, France.
5
Université Côte d'Azur, CNRS, Inserm, iBV, France. Electronic address: pisani@unice.fr.

Abstract

Oxylipins are bioactive metabolites derived from the oxygenation of ω3 and ω6 polyunsaturated fatty acids, triggered essentially by cyclooxygenase and lipoxygenase activities. Oxylipins are involved in the development and function of adipose tissue and their productions are strictly related to diet quality and quantity. Oxylipins signal via cell surface membrane (G Protein-coupled receptors) and nuclear receptors (peroxisome proliferator-activated receptors), two pathways playing a pivotal role in adipocyte biology. In this review, we made an attempt to cover the available knowledge about synthesis and molecular function of oxylipins known to modulate adipogenesis, adipocyte function and phenotype conversion, with a focus on their interaction with peroxisome proliferator-activated nuclear receptor family.

KEYWORDS:

Adipocyte; Eicosanoid; PPARα; PPARβ/δ; PPARγ; Prostanoid

PMID:
28034718
DOI:
10.1016/j.biochi.2016.12.012
[Indexed for MEDLINE]
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