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Ann Allergy Asthma Immunol. 2017 Feb;118(2):197-203. doi: 10.1016/j.anai.2016.11.013. Epub 2016 Dec 27.

Staphylococcus aureus enterotoxin sensitization involvement and its association with the CysLTR1 variant in different asthma phenotypes.

Author information

1
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Kinki Hokuriku Airway Disease Conference, Osaka, Japan. Electronic address: hmatsumo@kuhp.kyoto-u.ac.jp.
2
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Kinki Hokuriku Airway Disease Conference, Osaka, Japan.
3
Kinki Hokuriku Airway Disease Conference, Osaka, Japan; Department of Respiratory Medicine and Allergology, Faculty of Medicine, Kinki University, Osaka, Japan.
4
Kinki Hokuriku Airway Disease Conference, Osaka, Japan; Department of Respiratory Internal Medicine, Fujita Health University Second Educational Hospital, Aichi, Japan.
5
Kinki Hokuriku Airway Disease Conference, Osaka, Japan; Department of Respiratory Medicine, Takatsuki Red Cross Hospital, Osaka, Japan.
6
Kinki Hokuriku Airway Disease Conference, Osaka, Japan; Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Hyogo, Japan.
7
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Kinki Hokuriku Airway Disease Conference, Osaka, Japan; Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Hyogo, Japan.
8
Kinki Hokuriku Airway Disease Conference, Osaka, Japan; Department of Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
9
Kinki Hokuriku Airway Disease Conference, Osaka, Japan; Department of Hematology and Respiratory Medicine, Kochi University, Kochi, Japan.
10
Kinki Hokuriku Airway Disease Conference, Osaka, Japan; Division of Respiratory Medicine, Department of Internal Medicine, Shiga University of Medical Science, Shiga, Japan.
11
Kinki Hokuriku Airway Disease Conference, Osaka, Japan; Hiroshima Allergy and Respiratory Clinic, Hiroshima, Japan.
12
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
13
Shino-Test Corporation, Kanagawa, Japan.
14
Department of Laboratory Medicine, Saga Medical School, Saga, Japan.
15
Laboratory for Respiratory and Allergic Diseases, Core for Genomic Medicine, Center for Integrative Medical Sciences, Institute of Physical and Chemical Research, Yokohama, Kanagawa, Japan.
16
Center for Genomic Medicine, Kyoto University, Kyoto, Japan.
17
Department of Health Promotion, National Institute of Public Health, Wako, Saitama, Japan.
18
Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.
19
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Kinki Hokuriku Airway Disease Conference, Osaka, Japan; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University School of Medical Sciences, Aichi, Japan.

Abstract

BACKGROUND:

Sensitization to Staphylococcus aureus enterotoxin (SE) is a known risk factor for asthma susceptibility and severity. However, how SE sensitization is involved in asthma, particularly nonatopic asthma and/or late-onset asthma, remains uncertain.

OBJECTIVE:

To clarify the involvement of SE sensitization in nonatopic and/or late-onset asthma and its association with a polymorphism of the cysteinyl leukotriene receptor 1 gene (CysLTR1), which was examined because CysLT signaling is closely associated with late-onset eosinophilic asthma.

METHODS:

We assessed associations between sensitization to SE (A and/or B) and clinical indexes in 224 patients with asthma (mean age, 62.3 years; 171 women) from a cohort of the Kinki Hokuriku Airway Disease Conference, particularly those with nonatopic asthma (not sensitized to common aeroallergens) and/or late-onset asthma. Associations between SE sensitization and CysLTR1 polymorphism (rs2806489), a potential regulatory variant for atopic predisposition in women, were also assessed in a sex-stratified manner.

RESULTS:

A total of 105 patients (47%) with asthma were sensitized to SE. Among patients with nonatopic asthma (n = 67) or with late-onset asthma (n = 124), those sensitized to SE had significantly higher serum total IgE and periostin levels than those not sensitized. In nonatopic patients, a rapid decrease in forced expiratory volume in 1 second was associated with SE sensitization. In women with asthma, rs2806489 was associated with sensitization to SEB and age at asthma onset.

CONCLUSION:

SE sensitization contributes to TH2 inflammation in nonatopic and/or late-onset asthma. In women with asthma, the CysLTR1 variant might be associated with sensitization to SEB and age at asthma onset.

PMID:
28034578
DOI:
10.1016/j.anai.2016.11.013
[Indexed for MEDLINE]

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