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Nat Methods. 2016 Dec 29;14(1):18-22. doi: 10.1038/nmeth.4111.

Reversible RNA modifications in meiosis and pluripotency.

Author information

1
Department of Microbiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
2
Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
3
Norwegian Center for Stem Cell Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
4
Department of Gynecology, Section for Reproductive Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Abstract

Post-transcriptional RNA modifications were discovered several decades ago, but the reversible nature of RNA modifications has only recently been discovered. Owing to technological advances, knowledge of epitranscriptomic marks and their writers, readers and erasers has recently advanced tremendously. Here we focus on the roles of the dynamic methylation and demethylation of internal adenosines in mRNA in germ cells and pluripotent stem cells.

PMID:
28032624
DOI:
10.1038/nmeth.4111
[Indexed for MEDLINE]

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