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Nanotechnology. 2017 Feb 3;28(5):055604. doi: 10.1088/1361-6528/28/5/055604. Epub 2016 Dec 29.

Zeolitic imidazolate framework-8 (ZIF-8) as a sacrificial template: one-pot synthesis of hollow poly(dopamine) nanocapsules and yolk-structured poly(dopamine) nanocomposites.

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1
School of Chemical Engineering, Guizhou Institute of Technology, Guiyang 550003, People's Republic of China. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, People's Republic of China. Photoelectric Institute of Functional Materials, Guizhou Institute of Technology, Guiyang 550003, People's Republic of China.

Abstract

Hollow poly(dopamine) (PDA) nanocapsules and yolk-structured PDA nanocomposites were prepared by an aqueous one-pot synthesis method utilizing zeolitic imidazolate framework-8 (ZIF-8) nanocrystals as a sacrificial template without any special etchant. The resulting PDA nanocapsules show negligible cytotoxicity in HeLa cells after incubation for 48 h at various doses, which implies their potential as candidates for practical applications in drug transport and targeting.

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