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Adolesc Health Med Ther. 2016 Dec 16;8:1-10. doi: 10.2147/AHMT.S103396. eCollection 2017.

Acanthosis nigricans in obese adolescents: prevalence, impact, and management challenges.

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Department of Paediatrics and Adolescent Medicine, Tseung Kwan O Hospital, Tseung Kwan O, Hong Kong, China.


Obesity in adolescence is a public health priority because it usually tracks into adulthood, resulting in enormous medical and social costs. This underscores the importance of early identification and intervention. Acanthosis nigricans (AN) was once considered a rare paraneoplastic dermatosis, but is now frequently observed in obese adolescents. Current understanding suggests that it is associated with insulin resistance and has a unique role in secondary prevention. The purpose of this narrative review is to provide a comprehensive overview of AN in obese adolescents, covering its history, current knowledge on the condition, its clinical significance, management challenges, and the direction of future research.


Differential diagnosis; bariatric surgery; behavioral weight management; insulin resistance; metabolically healthy obesity; pharmacotherapy; screening; type 2 diabetes mellitus

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The author reports no conflicts of interest in this work.

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