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Nat Genet. 2016 Dec 28;49(1):5-6. doi: 10.1038/ng.3754.

Copy number alterations unmasked as enhancer hijackers.

Author information

1
Dana-Farber Cancer Institute, the Broad Institute of Harvard and MIT, and Harvard Medical School, Boston, Massachusetts, USA.

Abstract

Our understanding of how DNA copy number changes contribute to disease, including cancer, has to a large degree been focused on the changes in gene dosage that they generate and has neglected the effects of the DNA rearrangements that lead to their formation. A new study reports an innovative analytical framework for copy number alterations that are oncogenic primarily owing to the genomic rearrangements that underlie them.

PMID:
28029156
DOI:
10.1038/ng.3754
[Indexed for MEDLINE]

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