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J Agric Food Chem. 2017 Jan 25;65(3):586-595. doi: 10.1021/acs.jafc.6b04408. Epub 2017 Jan 11.

Adherence to a Mediterranean Diet Influences the Fecal Metabolic Profile of Microbial-Derived Phenolics in a Spanish Cohort of Middle-Age and Older People.

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Department of Functional Biology, University of Oviedo , C/Julián Clavería s/n, Oviedo, 33006 Asturias, Spain.
Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias-Consejo Superior de Investigaciones Científicas (IPLA-CSIC) , Paseo Río Linares s/n, Villaviciosa, 33300 Asturias, Spain.
Institute of Food Science Research (CIAL), CSIC-UAM, CEI UAM-CSIC , C/Nicolás Cabrera 9, 28049 Madrid, Spain.
Department of Applied Mathematics, University of Oviedo , C/Calvo Sotelo, 33007 Asturias, Spain.


Despite the evidence regarding the influence of certain polyphenol food sources on the metabolic profile in feces, the association between the different phenolics provided by the diet and the fecal phenolic profile has not been elucidated. In this study, the composition of phenolic metabolites in fecal solutions was analyzed by UPLC-ESI-MS/MS in 74 volunteers. This fecal phenolic profile showed a high interindividual variation of the different compounds analyzed, phenylacetic and phenylpropionic acids being the major classes of phenolic metabolites excreted in feces. Subjects with higher adherence to a Mediterranean dietary pattern presented greater fecal concentrations of benzoic and 3-hydroxyphenylacetic acids, positively correlated with the intake of the principal classes and subclasses of polyphenols and fibers, and higher levels of Clostridium cluster XVIa and Faecalibacterium prausnitzii. These results provide a link among the Mediterranean dietary pattern, the bioactive compounds of the diet, and the fecal metabolic phenolic profile.


Mediterranean dietary pattern; fecal metabolites excretion; fiber; phenolic compounds; physical activity

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