Format

Send to

Choose Destination
Endocrinol Metab (Seoul). 2016 Dec;31(4):598-603. doi: 10.3803/EnM.2016.31.4.598.

Obesity and Hyperglycemia in Korean Men with Klinefelter Syndrome: The Korean Endocrine Society Registry.

Author information

1
Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea.
2
Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
3
Department of Internal Medicine, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
4
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
5
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
6
Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
7
Division of Endocrinology, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.
8
Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
9
Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.
10
Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
11
Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
12
Division of Endocrinology and Metabolism, Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.
13
Department of Endocrinology, Inha University School of Medicine, Incheon, Korea.
14
Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea. yschung@ajou.ac.kr.

Abstract

BACKGROUND:

The aim of this study was to investigate the prevalence of obesity in Korean men with Klinefelter syndrome (KS) and the associated risk factors for obesity and hyperglycemia.

METHODS:

Data were collected retrospectively from medical records from 11 university hospitals in Korea between 1994 and 2014. Subjects aged ≥18 years with newly diagnosed KS were enrolled. The following parameters were recorded at baseline before treatment: chief complaint, height, weight, fasting glucose level, lipid panel, blood pressure, testosterone, luteinizing hormone, follicle-stimulating hormone, karyotyping patterns, and history of hypertension, diabetes, and dyslipidemia.

RESULTS:

Data were analyzed from 376 of 544 initially enrolled patients. The rate of the 47 XXY chromosomal pattern was 94.1%. The prevalence of obesity (body mass index ≥25 kg/m²) in Korean men with KS was 42.6%. The testosterone level was an independent risk factor for obesity and hyperglycemia.

CONCLUSION:

Obesity is common in Korean men with KS. Hypogonadism in patients with KS was associated with obesity and hyperglycemia.

KEYWORDS:

Hyperglycemia; Klinefelter syndrome; Obesity

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Supplemental Content

Full text links

Icon for Korean Endocrine Society Icon for PubMed Central
Loading ...
Support Center