Format

Send to

Choose Destination
Antioxid Redox Signal. 2017 Aug 10;27(5):276-310. doi: 10.1089/ars.2016.6782. Epub 2017 Feb 6.

Redox Control of Skeletal Muscle Regeneration.

Author information

1
1 Institut NeuroMyoGène, Université Claude Bernard Lyon 1 , INSERM U1217, CNRS UMR 5310, Villeurbanne, France .
2
2 Movement, Sport and Health Sciences Laboratory, M2S, EA1274, University of Rennes 2 , Bruz, France .
3
3 Laboratoire Interuniversitaire de Biologie de la Motricité, EA7424, Université Claude Bernard Lyon 1 , Univ Lyon, Villeurbanne, France .
4
4 Institut Universitaire de France , Paris, France .

Abstract

Skeletal muscle shows high plasticity in response to external demand. Moreover, adult skeletal muscle is capable of complete regeneration after injury, due to the properties of muscle stem cells (MuSCs), the satellite cells, which follow a tightly regulated myogenic program to generate both new myofibers and new MuSCs for further needs. Although reactive oxygen species (ROS) and reactive nitrogen species (RNS) have long been associated with skeletal muscle physiology, their implication in the cell and molecular processes at work during muscle regeneration is more recent. This review focuses on redox regulation during skeletal muscle regeneration. An overview of the basics of ROS/RNS and antioxidant chemistry and biology occurring in skeletal muscle is first provided. Then, the comprehensive knowledge on redox regulation of MuSCs and their surrounding cell partners (macrophages, endothelial cells) during skeletal muscle regeneration is presented in normal muscle and in specific physiological (exercise-induced muscle damage, aging) and pathological (muscular dystrophies) contexts. Recent advances in the comprehension of these processes has led to the development of therapeutic assays using antioxidant supplementation, which result in inconsistent efficiency, underlying the need for new tools that are aimed at precisely deciphering and targeting ROS networks. This review should provide an overall insight of the redox regulation of skeletal muscle regeneration while highlighting the limits of the use of nonspecific antioxidants to improve muscle function. Antioxid. Redox Signal. 27, 276-310.

KEYWORDS:

muscle stem cells; oxidative stress; skeletal muscle regeneration

PMID:
28027662
PMCID:
PMC5685069
DOI:
10.1089/ars.2016.6782
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center