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J Nat Prod. 2017 Jan 27;80(1):201-204. doi: 10.1021/acs.jnatprod.6b00493. Epub 2016 Dec 27.

Monascustin, an Unusual γ-Lactam from Red Yeast Rice.

Author information

1
Beiijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University , Beijing 100191, People's Republic of China.
2
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
3
Lanzhou University First Affiliated Hospital , Gansu 730000, People's Republic of China.

Abstract

Monascustin (1), an unusual γ-lactam, was isolated from an ethanol extract of the Monascus purpureus fermented rice. Its structure including the absolute configuration was determined by spectroscopic data analysis and confirmed by X-ray crystallography. A plausible biosynthetic pathway is discussed on the basis of amino acid derivatization. Compound 1 showed inhibitory activity against histone deacetylase 1.

PMID:
28026946
DOI:
10.1021/acs.jnatprod.6b00493
[Indexed for MEDLINE]

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