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Appl Radiat Isot. 2017 Mar;121:38-43. doi: 10.1016/j.apradiso.2016.11.021. Epub 2016 Dec 21.

Optimized procedures for manganese-52: Production, separation and radiolabeling.

Author information

1
Hevesy Laboratory, Center for Nuclear Technologies, Technical University of Denmark, Frederiksborgvej 399, 4000 Roskilde, Denmark.
2
Department of Medical Physics, University of Wisconsin - Madison, Madison, WI 53706, United States.
3
Hevesy Laboratory, Center for Nuclear Technologies, Technical University of Denmark, Frederiksborgvej 399, 4000 Roskilde, Denmark; Department of Chemistry, Michigan State University, East Lansing, MI 48824, United States; Facility for Rare Isotope Beams, Michigan State University, East Lansing, MI 48824, United States. Electronic address: gwseverin@chemistry.msu.edu.

Abstract

Pressed chromium-powder cyclotron targets were irradiated with 16MeV protons, producing 52Mn with average yields of 6.2±0.8MBq/µAh. Separation by solid-phase anion exchange from ethanol-HCl mixtures recovered 94.3±1.7% of 52Mn and reduced the chromium content by a factor of 2.2±0.4×105. An additional AG 1-X8 column was used to remove copper, iron, cobalt and zinc impurities from the prepared 52Mn in 8M HCl. The macrocyclic chelator DOTA was rapidly radiolabeled with 52Mn in aq. ammonium acetate (pH 7.5R.T.) with a radiochemical yield >99% within 1min and was stable for >2 days in bovine serum. The improved separation and purification methodology facilitates the use of 52Mn in basic science and preclinical investigations.

KEYWORDS:

(52)Mn; Cyclotron; DOTA; Isotope production; Manganese; Mn-52; PET; Serum stability

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