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Nat Neurosci. 2017 Feb;20(2):189-199. doi: 10.1038/nn.4467. Epub 2016 Dec 26.

Developmental broadening of inhibitory sensory maps.

Author information

1
Department of Molecular &Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
2
Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA.
3
Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA.
4
Medical Scientist Training Program, Baylor College of Medicine, Houston, Texas, USA.
5
SMART Program, Baylor College of Medicine, Houston, Texas, USA.
6
University of St. Thomas, Houston, Texas, USA.
7
Allen Institute for Brain Science, Seattle, Washington, USA.
8
Department of Electrical and Computer Engineering, Rice University, Houston, Texas, USA.
9
Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas, USA.

Abstract

Sensory maps are created by networks of neuronal responses that vary with their anatomical position, such that representations of the external world are systematically and topographically organized in the brain. Current understanding from studying excitatory maps is that maps are sculpted and refined throughout development and/or through sensory experience. Investigating the mouse olfactory bulb, where ongoing neurogenesis continually supplies new inhibitory granule cells into existing circuitry, we isolated the development of sensory maps formed by inhibitory networks. Using in vivo calcium imaging of odor responses, we compared functional responses of both maturing and established granule cells. We found that, in contrast to the refinement observed for excitatory maps, inhibitory sensory maps became broader with maturation. However, like excitatory maps, inhibitory sensory maps are sensitive to experience. These data describe the development of an inhibitory sensory map as a network, highlighting the differences from previously described excitatory maps.

PMID:
28024159
PMCID:
PMC5510602
DOI:
10.1038/nn.4467
[Indexed for MEDLINE]
Free PMC Article

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